At least three officers from the Afghan National Army (ANA) were killed and three others wounded when a suicide bomber detonated explosives in front of an army checkpoint in PD1 in Behsud Pul square in Jalalabad city, security sources said.
One civilian was also wounded in the attack.
Provincial officials confirm a security forces checkpoint in PD1 in Behsud Pul Square in Jalalabad city was targeted in the suicide bombing just before 7pm on Sunday.
But Attaullah Khogyani, a spokesman for the provincial governor said that an army officer who was checking the suicide bomber was killed and five others were wounded.
Health officials said one person was killed and four others wounded.
The latest explosion comes in the wake of a string of attacks that have rocked the city in the past few weeks.
Last week a deadly attack was carried out on a refugee center in the city which lasted over six hours and left more than 15 people dead.
The day after the attack President Ashraf Ghani held an emergency meeting on the security situation in Nangarhar and ordered security to be stepped up in the province.
He ordered the Afghan National Army (ANA) to work with the Afghan National Police (ANP) police to secure the province.